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Best Diacetyl-Free E-Juices 2019 – Top Brands, and Flavors At The Best Prices of 2019

Diacetyl is a chemical that occurs in low concentration in coffee, honey, apples, vinegar, and tobacco. It is used by manufacturers to add a buttery taste to products like oil sprays, snack food, margarine and lately e-juices. Heated diacetyl may cause coughing and lead to respiratory sickness. Thus diacetyl-free e-juice flavoring is in high demand among savvy vapers – and for a good reason. E-liquid companies are aware of this and for the most part, have made conscious efforts in reducing or eliminating this chemical. Some manufacturers took this step and started producing superior, safe e-juices that deserve top charts positions.

Are you looking for diacetyl-free e-juice? There is a lot of vape juice that claims to be a lot of things. Organic, vegan, cruelty-free, non-GMO… the list goes on. How do you know which ones are being honest? The best companies post lab results and certifications to back up their claims.

Never sacrifice flavor for safety! All of the products below have been tested and verified for quality. See the test results and learn more about diacetyl free e-juice in the guide below. If you want to jump right into it, here are the top seven best-tasting diacetyl-free e-juices available right now.

Best Diacetyl-Free E-Juices

Check out top e-juices by the most trusted brands.

Strawberry Shortcake Ice Cream
Strawberry Shortcake Ice Cream
Located in Orange County, California, cosmic vapors strives to provide only the highest quality e-liquids. The process begins in an FDA registered lab, using the latest manufacturing equipment and technology. Their glycerin is “top rated” and extracted from soybeans, making it safe for those with peanut allergies. Most importantly, the quality of their flavorings exceeds food grade by being specially designed for inhalation. Delicately balanced to provide a blast of strawberry flavor with a creamy ice cream undertone, this delicious all-day vape has been received with almost universal acclaim.
Kind Juice
Kind Juice
Kind Juice provides a departure from your typical boring e-juice. They use natural extracts and organic ingredients with no artificial sweeteners or diacetyl. It’s some of the most unique e-liquid available. Their range spans from tobacco to floral and fruit nectar flavors. Each one is formulated with max VG.
KAI's Virgin Vapor
KAI's Virgin Vapor
KAI’s Virgin Vapor might be clean as it gets. They perform testing to ensure diacetyl-free e-juice with state of the art GC-MS testing. They also use USP and kosher-grade ingredients and third-party organic flavorings. There’s a whole spectrum of flavors to choose and all of their e-juice contains maximum VG content.
Cosmic Fog
Cosmic Fog
Cosmic Fog has some of the most unique flavors out there. Thoroughly tested and crafted by vapers who have a background in culinary arts. All of them are made in an ISO 8 laboratory and are free of diacetyl and other contaminants. Each flavor provides a completely new experience for your taste buds.
Black Note
Black Note
Black Note provides premium e-juice for the true tobacco connoisseur. They’re all made with real tobacco using a natural extraction process. The flavors are robust, authentic and diacetyl-free. There’s also a variety of menthol flavors made with natural peppermint oil extract. Each flavor comes in a 50/50 VG/PG blend.
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Why vape diacetyl-free e-juice?

Diacetyl, called DA for short, is a naturally occurring compound found in the fermentation of beer. It’s also synthesized and used as a flavoring agent in food products for its rich mouthfeel and buttery taste. The scare over it has to do with it being the likely culprit in eight cases of popcorn lung, a deadly and irreversible lung disease that affected popcorn factory workers during the 1990s.

DA is safe to consume in foods, but it poses risks for inhalation. The popcorn factory workers were repeatedly exposed to industrial-sized vats of the chemical mixed with hot oil, which is far from the trace amounts found in any e-juice. But even if the risks are minor in comparison, many vapers want to avoid it.

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Health Benefits of diacetyl-free E-Liquid

According to the Centers for Disease Control (CDC), diacetyl is best known for its use in popcorn flavorings (but has since found itself in many e-liquids). It was eventually associated with lung damage, resulting in decreased respiratory function. Animal studies by the CDC also showed severe lung impact following diacetyl exposure. Frequent vapers greatly significantly reduce potential respiratory harm by avoiding this substance.

Diacetyl is safe to ingest, but the research shows it is hazardous when inhaled. This chemical is not a necessary component in e-liquids, so always research the product in order to prevent potential lung damage..

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Where Can Consumers Find diacetyl-free E-Juice Vendors?


NoIDDiacetyl (μg/ml)
1GrandmasterND < 5
2Gambit16.0
3Castle LongND < 5
4Sixty-FourND < 5
5Lucena24.8
6Fifth RankND < 5
7Absolute Pin8.4
8Perpetual Check130.8
9Bowden’s MateND < 5
10QueensideND < 5

The lab test results from several e-juices shows that diacetyl has been found in varying degrees, depending on the flavor.

The letters “ND” stand for “non-detect,” implying that the amounts were too insignificant for the equipment to find any diacetyl. This legend is universally used in third-party lab analyses, making the results simple to read and allowing consumers to identify diacetyl-free e-liquid easily.

Lab tests published by Harvard University in June 2016 found that diacetyl was most prominent in tobacco and menthol flavored e-liquids; however, the e-cigarette industry has evolved considerably year over year. While menthol and tobacco are likely culprits for diacetyl, they do not universally contain it.

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Why aren’t all e-juices diacetyl-free?

After a 2014 study conducted by Dr. Farsalinos showed many e-juices on the market contained detectable amounts of DA, the hunt for diacetyl-free e-juice was on. The tricky part was finding them. Many of those companies in the study claimed their products were diacetyl-free, though the liquids in fact did test positive for it in Dr. Farsalinos’s study. Were they all lying?

As it turns out, the likelihood that any e-juice maker was (is) directly using DA as an ingredient is slim to none. It resides in some of the flavorings used to make the e-juice. In the earlier days of vaping, little was known about this fact. E-liquid manufacturers knew they weren’t adding some flavoring called diacetyl, but what they didn’t know was that it was hiding in plain sight. The only way now to be certain if an e-juice is DA-free is by having it independently tested by a third-party source like Enthalpy Labs. Many companies like the ones listed on this page in fact have these test results.

But not all vapers are concerned. For one, DA and its related chemicals called diketones add a rich flavor to e-juice that many vapers enjoy. Secondly, because DA is also one of the thousands of chemicals in cigarettes, and at levels 100 times higher (or more) than in e-juice, some vapers are willing to take the risk. If you were or are a smoker, you’ve already inhaled it – and a lot of it! Many vapers view the risks of DA in vaping as reduced harm since its content in cigarettes is so much more extreme.

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Is diacetyl-free the safest e-liquid to vape?

The most suspect aspects of vape juice have to do with the inhalation of the vape flavorings. Eliminating any non-essential elements from e-juice will in fact make it safer. But if you want the absolute safest e-juice, you’re best off using unflavored. If unflavored vape juice doesn’t appeal to you, vaping diacetyl-free e-juice is at the very least a safer option than e-juice with it. But if your only other option is smoking, it almost doesn’t matter what you vape. Vaping is the safer choice and is at least 95% safer than smoking.

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Test results for brands on this page

Vapesnational assumes no liability for claims from e-juice companies. All objective information on this page was provided to us directly from the manufacturer or the company’s website. Contact the manufacturer for more information on their ingredients, manufacturing processes, testing procedures, and test results.

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Quick Facts About Diacetyl

  • Although used in artificial flavorings, diacetyl is created naturally through yeast fermentation.
  • In addition to buttery flavors, diacetyl is used in some Chardonnay wines and a wide variety of fruit flavors consumed on a daily basis.
  • Diacetyl gained infamy when it was linked to a condition called bronchiolitis obliterans – colloquially referred to as “popcorn lung” due to the harmful effects of its inhalation popcorn factories that lacked ventilation.

Diacetyl in Vape Juice vs CigarettesIs Diacetyl Negatively Affecting Vapers?

While diacetyl exposure in cigarette users is far greater than that in vapers, the chemical should still be avoided when possible. Small amounts of diacetyl are still potentially harmful, and diacetyl free vape juices are potentially less harmful than those that include diacetyl.

A report from the Department of Environmental Medicine and the University of Rochester Medical Center in Rochester, New York affirms the idea that diacetyl free e juice is less harmful than vape juices with diacetyl.

This report assesses the risk of diacetyl to vapers and concludes that vape juice without diacetyl is potentially less harmful.

The report concluded that exposure to diacetyl when vaping caused a significant biological inflammatory response. According to the same report, diacetyl in vape juice could potentially be toxic to the lungs and could potentially cause damage to the user’s bodily tissue.

Diacetyl is potentially harmful to the lungs, and avoiding it is a sensible precaution that a lot of vapers are taking. Luckily, there are a lot of vape brands that make diacetyl free vape juice for vapers that don’t want to take the risk.

Fortunately, there are thousands of brands and flavors available that not only avoid diacetyl but also use very high quality, reputable ingredients. The aura of transparency and responsibility in the e-liquid market is truly notable, so vapers everywhere should support and promote diacetyl-free e-liquid brands.

Diacetyl – like many substances – is both benign and dangerous. Although safely used for years as a food flavoring, it is clear that the substance is unsafe for inhalation.

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